High Throughput Screening

[ See Screen Details ]

Plate Manager provides a generic framework to link your corporate database with your laboratory instruments. The application of this generic software to your specific environment is realized through the creation of site-specific plug-ins. Plate Manager provides a suite of basic plug-ins that can be modified to fit your specific needs. It is this combination of Plate Manager's generic features and your custom plug-ins that work together to increase throughput. For example,

• Select a plate template from the library of standard protocols
• Call a plug-in that enables a technician to point and click on a list of compounds from the inventory database to assign them to a plate
• Enter the starting dilution for each sample and dilute them automatically
• Call a plug-in to write instructions for laboratory instruments
• Call a plug-in to print the plate design
• Save the plate design to a database
• Call a plug-in to import data from the plate reader
• Call a plug-in to tab through the experimental groups to analyze, view, and edit results
• Save results to the database and email them to a colleague

Features

Plate Design

• Create plates of any X-Y dimension
• Add contents (e.g., media, drugs, targets, host cells and indicators) to individual wells
• Assign related wells to groups
• Dilute components automatically by group
• Convert validated plates into screening templates that can be copied but not changed
• Notify technicans about deviations from the parent template
• Link technician notes with individual plates

Plug-ins

Plug-ins are simple programs that you use to integrate Plate Manager with the local environment.

• Import plug-ins interface with an inventory database to register compounds and plates in Plate Manager
• Capture plug-ins import ASCII result files generated by laboratory instruments
• Analysis plug-ins run the statistical analyses of your choice and display them as graphs and tables for review, revision, discard, or storage.
• Instrument plug-ins format data on each plate into instructions for laboratory robots
• Export plug-ins copy results to the appropritae database tables
• Print plug-ins generate HTML documents on the fly and open them in a local browser for printing
• Help plug-ins are used to link HTML documentation to the menu bar

Technology

• Runs as a stand-alone application over a local database or as a network client linked to servers running the corporate database
• Runs clients on windows or Java virtual machines
• Server software runs on major operating systems: AIX, HP/UX, MVS, DEC Unix, Linux, OpenVMS, Solaris, Win95/98/NT
• Simultaneous connections to commercial relational databases are supported: ADABAS D, DB2, Informix, ODBC, Oracle, Rdb, SQL Server, and Sybase
• Access is also provided to non-relational databases such as ADABAS C and SDMS (ISAM)
• Developed in DesignVision by Trifox, Inc.
• Reports are generated in real-time, displaying and printing from web browsers
• Delimited ascii files are exported to spreadsheets and editors